• Early, Midlife Infections Up Alzheimer's, Parkinson's Risk

    1 day ago - By MedPageToday

    Early and midlife infections treated in outpatient or inpatient hospital settings upped the risk of a subsequent Alzheimer's or Parkinson's disease diagnosis, a case-control study in Sweden showed.
    A hospital-treated infection...
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  • Crenezumab not effective in treating Alzheimer's disease

    Crenezumab not effective in treating Alzheimer's disease

    1 day ago - By Healio

    Although it was well tolerated, the anti-amyloid antibody crenezumab did not reduce clinical decline in patients with Alzheimer's disease, researchers reported in JAMA Neurology.
    Susanne Ostrowitzki, MD, of F. Hoffman-La Roche Ltd., in Sweden, and colleagues assessed the safety and efficacy of crenezumab, a humanized monoclonal immunoglobulin G4 antibody that targeted beta-amyloid oligomers in patients with prodromal to mild AD.
    Two phase 3 multicenter, randomized, double-blind studies of crenezumab were initiated in 2016 and 2017. The first included 194 sites in 30 countries (n = 3,736
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