• Maternal dietary inflammatory potential and quality are associated with offspring asthma risk over 10-year follow-up: the Lifeways Cross-Generation Cohort Study

    7 monthes ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundAsthma is the most common childhood chronic health condition. Maternal antenatal diet has been associated with offspring asthma risk, but studies investigating maternal whole diet quality and inflammatory potential with long-term offspring follow-up are rare.ObjectivesWe aimed to elucidate these associations in a prospective cohort study in Ireland.MethodsEarly pregnancy diets were assessed using a validated FFQ from which energy-adjusted Dietary Inflammatory Index and Healthy Eating Index -2015 scores were computed. Doctor-diagnosed offspring asthma status for the first...
    Read more ...

     

  • Maternal MTNR1B genotype, maternal gestational weight gain, and childhood obesity

    7 monthes ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundMaternal metabolic abnormalities have been related to offspring obesity especially during childhood.ObjectivesWe analyzed whether the gestational diabetes mellitus -associated melatonin receptor 1B genotype of mothers modified the relation between maternal gestational weight gain and childhood obesity.MethodsA total of 1114 Chinese mother-child pairs were included. Mothers' MTNR1B rs10830962 genotype and gestational weight gain were assessed. Indicators of childhood obesity included BMI-for-age z-score, weight-for-age z-score, waist circumference, and body fat. Childhood...
    Read more ...