• Randomization to a Liberal Versus Conservative Oxygenation Target: Redox Responses in Critically Ill Children

    2 monthes ago - By Pediatric Critical Care Medicine

    Optimal systemic oxygenation targets in pediatric critical illness are unknown. A U-shaped relationship exists between blood oxygen levels and PICU mortality. Redox stress or iatrogenic injury from intensive treatments are potential mechanisms of harm from hyperoxia.
    To measure biomarkers of oxidative status in children admitted to PICU and randomized to conservative (oxygen-hemoglobin saturation 88-92%) versus liberal peripheral oxygenation targets.
    Mechanistic substudy nested within the Oxygen in PICU pilot randomized feasibility clinical trial...
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