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Randomization to a Liberal Versus Conservative Oxygenation Target: Redox Responses in Critically Ill Children
2 monthes ago - By Pediatric Critical Care Medicine
Rationale:
Optimal systemic oxygenation targets in pediatric critical illness are unknown. A U-shaped relationship exists between blood oxygen levels and PICU mortality. Redox stress or iatrogenic injury from intensive treatments are potential mechanisms of harm from hyperoxia.
Objectives:
To measure biomarkers of oxidative status in children admitted to PICU and randomized to conservative (oxygen-hemoglobin saturation 88-92%) versus liberal peripheral oxygenation targets.
Design:
Mechanistic substudy nested within the Oxygen in PICU pilot randomized feasibility clinical trial...
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