Only higher-dose tramadol outperforms placebo for improved pain, function in knee, hip OA
1 month ago - By Healio
A daily 300 mg dose of tramadol - but not 100 or 200 mg doses - surpassed placebo in improving pain and function related to hip or knee osteoarthritis, but was linked to increasing adverse events, researchers noted in Arthritis Care & Research.
“It was reported that the prescription for tramadol had increased by 22.8% from 2012 to 2015 in the USA,” Xiurui Zhang, MD, of Xiangya Hospital, Central South University, in Changsha, China, and colleagues wrote. “For OA patients, tramadol was most commonly prescribed as the first option of the opioid drug .
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