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Experimental Drug Reverses Hair Loss and Skin Damage in Mice

Posted On: Aug 3, 2018   |   Posted By: Surgical Aesthetics Magazine

Experimental Drug Reverses Hair Loss and Skin Damage in Mice

A recent mouse study from Johns Hopkins, published in Scientific Reports , shows that an experimental drug can successfully reverse hair loss, hair whitening and skin inflammation linked by previous studies to human diets heavy in fat and cholesterol.
In a series of experiments with mice, Johns Hopkins investigators used an experimental compound-D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol -that halts the production of glycosphingolipids , which are major components of skin and other cell membranes. Earlier research revealed that GSLs are prevalent in the cells that make up the uppermost layer of the skin, as well as in keratinocytes that help regulate pigmentation of the eyes, skin and hair. Mice fed a diet high in fat and cholesterol are more likely to have hair discoloration , extensive hair loss and inflammation of skin exhibited by multiple wounds. Feeding these animals D-PDMP, however, appears to reverse such symptoms.
The investigators...

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