• Checkpoint inhibition and rheumatic events: ‘Many more questions than answers'

    5 monthes ago - By Healio

    It may seem silly to use Whac-A-Mole to illustrate a key challenge in cancer treatment.
    But the popular arcade game's basic premise - use a mallet to knock one mole back into its hole, only to have another pop up a split-second later - is a fitting comparison to the immune-related adverse events that can arise during treatment with checkpoint inhibitors.
    Checkpoint inhibition - the foundation of the immunotherapy revolution in oncology - targets checkpoints, or regulators, that inhibit or stimulate the immune system's actions. Tumors use these checkpoints to
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