• Brain development measured with MRI in Children with Down syndrome correlates with blood biochemical biomarkers

    6 monthes ago - By Pediatric Neurology

    Down syndrome is a common genetic disorder that has cognitive consequences. People with DS exhibit age-related neurodegeneration and tend to develop Alzheimer's disease .1 Senile plaques and neurofibrillary tangles , common pathological changes in AD, have been detected in the brain of DS adults older than 30ཞ40 years.2 β-amyloid peptide , a neurotoxic hydrolyzed product of amyloid precursor protein, plays a role in SPs formation and relates to cognitive and mental behavior disorders.
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