Early changes to synapse gene regulation may cause Alzheimer's disease
11 days ago - By ScienceDaily
New research has revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was found to block its transport to the nucleus. This reduced levels of the PQBP1 protein, causing abnormal changes to the splicing of synapse genes and cognitive decline. These phenotypes were reversed by restoring PQBP1 function, suggesting a possible future treatment for AD.
Read more ...
Findings offer new insight into early changes that occur during AD pathology
11 days ago - By News Medical
Alzheimer's disease is the most common form of dementia, involving memory loss and a reduction in cognitive abilities.
Read more ...
Search by Tags
The headlines of Master Doctor
Blasting prostate tumours with radiotherapy CAN increase the chances of survival
Targeting the source of advanced prostate cancer with radiotherapy after the disease has spread could increase the patient's chances of survival by 11 per cent.
Chronic Inflammation Linked to Increased Alzheimer's Disease Risk
ApoE4 gene carriers who have chronic inflammation are more likely to develop Alzheimer's disease, finds a new study.
Latest Issue of Healthy Aging® Magazine Coming Soon!
What's inside the latest edition of Healthy Aging Magazine!
Age-Friendly Funding Alert: Transportation and Walkability
Thanks to the Healthy Aging Collaborative's partners at MassMobility, we are pleased to pass on a pair of funding opportunities relative to accessible transit and...
Carl Zeiss Meditec acquires miLOOP developer IanTECH
Carl Zeiss Meditec will acquire IanTECH, the developer of the miLOOP lens fragmentation device, expanding its cataract surgery portfolio, the company announced in a press...
Gene Therapy Shows Early Signs of Parkinson's Improvement
This MRI-guided approach transfers the gene therapy directly to specific regions of the brain where conversion to dopamine is impaired. Medscape Medical News
Pelvic lymph node treatment, short-term ADT improve outcomes in prostate cancer
The addition of pelvic lymph node treatment and short-term androgen deprivation therapy to prostate bed salvage radiotherapy reduced risk for disease progression among men with...
DBS Benefit in Alzheimer's May Only Extend to Older Patients
Preliminary results suggest that deep brain stimulation of the fornix is safe to use for 2 years and that it may have long-term benefit in patients with AD, but only in those...
Blood Biomarker Distinguishes Parkinson's from MSA
Alpha-synuclein levels in brain-derived exosomes highlight differences
VIDEO: The Ocular Surface: Critical for Refractive Cataract Surgery Success
NEW YORK - From OSN New York 2018, Darrell White, MD, founder of SkyVision Centers in Westlake, Ohio, gives his presentation on how the ocular surface is critical for...