• Glycolysis/gluconeogenesis- and tricarboxylic acid cycle-related metabolites, Mediterranean diet, and type 2 diabetes

    7 monthes ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundGlycolysis/gluconeogenesis and tricarboxylic acid cycle metabolites have been associated with type 2 diabetes. However, the associations of these metabolites with T2D incidence and the potential effect of dietary interventions remain unclear.ObjectivesWe aimed to evaluate the association of baseline and 1-y changes in glycolysis/gluconeogenesis and TCA cycle metabolites with insulin resistance and T2D incidence, and the potential modifying effect of Mediterranean diet interventions.MethodsWe included 251 incident T2D cases and 638 noncases in a nested case-cohort study...
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