• Dietary Patterns, Ceramide Ratios, and Risk of All-Cause and Cause-Specific Mortality: The Framingham Offspring Study

    8 days ago - By Nutrition

    ABSTRACTBackgroundPrior evidence suggests that diet modifies the association of blood ceramides with the risk of incident cardiovascular disease. It remains unknown if diet quality modifies the association of very long-chain-to-long-chain ceramide ratios with mortality in the community.ObjectivesOur objectives were to determine how healthy dietary patterns associate with blood ceramide concentrations and to examine if healthy dietary patterns modify associations of ceramide ratios with all-cause and cause-specific mortality.MethodsWe examined 2157 participants of the Framingham Offspring...
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  • A lipid-related metabolomic pattern of diet quality

    8 days ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundAdherence to a healthy diet has been associated with reduced risk of chronic diseases. Identifying nutritional biomarkers of diet quality may be complementary to traditional questionnaire-based methods and may provide insights concerning disease mechanisms and prevention.ObjectiveTo identify metabolites associated with diet quality assessed via the Alternate Healthy Eating Index and its components.MethodsThis cross-sectional study used FFQ data and plasma metabolomic profiles, mostly lipid related, from the Nurses' Health Study and Health Professionals Follow-up Study...
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