• Hepatic Expression of PEMT, but Not Dietary Choline Supplementation, Reverses the Protection against Atherosclerosis in Pemt−/−/Ldlr−/− Mice

    15 days ago - By Journal of Nutrition

    AbstractBackgroundPhosphatidylethanolamine N-methyltransferase converts phosphatidylethanolamine to phosphatidylcholine. Pemt −/− /low density lipoprotein receptor −/− mice have significantly reduced plasma lipids and are protected against atherosclerosis. Recent studies have shown that choline can be metabolized by the gut flora into trimethylamine-N-oxide , which is an emerging risk factor for atherosclerosis.ObjectiveThe objective of this study was to determine whether ectopic hepatic PEMT expression or choline supplementation would promote atherosclerosis in Pemt−/−/Ldlr−/−...
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