• Total and added sugar intakes, sugar types, and cancer risk: results from the prospective NutriNet-Santé cohort

    3 days ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundExcessive sugar intake is now recognized as a key risk factor for obesity, type 2 diabetes, and cardiovascular diseases. In contrast, evidence on the sugar-cancer link is less consistent. Experimental data suggest that sugars could play a role in cancer etiology through obesity but also through inflammatory and oxidative mechanisms and insulin resistance, even in the absence of weight gain.ObjectiveThe objective was to study the associations between total and added sugar intake and cancer risk , taking into account sugar types and sources.MethodsIn total, 101,279...
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  • Sugar intake and cancer risk: when epidemiologic uncertainty meets biological plausibility

    3 days ago - By American Journal of Clinical Nutrition

    Reprogramming metabolism is an emerging hallmark of cancer cells, with glycolysis as the main pathway of energy production, even when sufficient oxygen is present, a phenomenon referred to as the Warburg effect. Owing to this metabolic adaptation, cancer cells consume large quantities of glucose to survive through hypoxic conditions, commonly found in tumors, and support their anabolic requirements for uncontrolled growth and division. Therefore, dietary restriction of carbohydrates and pharmacologic agents that decrease insulin production or inhibit insulin signals have been exploited as...
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