• Diets Low in Saturated Fat with Different Unsaturated Fatty Acid Profiles Similarly Increase Serum-Mediated Cholesterol Efflux from THP-1 Macrophages in a Population with or at Risk for Metabolic Syndrome: The Canola Oil Multicenter Intervention

    2 monthes ago - By Journal of Nutrition

    AbstractBackgroundCholesterol efflux plays an important role in preventing atherosclerosis progression. Vegetable oils with varying unsaturated fatty acid profiles favorably affect multiple cardiovascular disease risk factors; however, their effects on cholesterol efflux remain unclear.ObjectiveThe objectives of this study were to examine the effects of diets low in saturated fatty acids with varying unsaturated fatty acid profiles on serum-mediated cholesterol efflux and its association with the plasma lipophilic index and central obesity.MethodsThe present study is a randomized...
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  • Selenium Supplementation Alters Hepatic Energy and Fatty Acid Metabolism in Mice

    2 monthes ago - By Journal of Nutrition

    AbstractBackgroundHuman and animal studies have raised concerns that supplemental selenium can increase the risk of metabolic disorders, but underlying mechanisms are unclear.ObjectiveWe used an integrated transcriptome and metabolome analysis of liver to test for functional pathway and network responses to supplemental selenium in mice.MethodsMale mice fed a standard diet were given selenium or vehicle for 16 wk. Livers were analyzed for selenium concentration, activity of selenoproteins, reduced glutathione redox state, gene expression, and high-resolution metabolomics. Transcriptomic...
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