• Targeted Metabolomics Analysis Reveals that Dietary Supranutritional Selenium Regulates Sugar and Acylcarnitine Metabolism Homeostasis in Pig Liver

    7 monthes ago - By Nutrition

    ABSTRACTBackgroundThe association between high selenium intake and metabolic disorders such as type 2 diabetes has raised great concern, but the underlying mechanism remains unclear.ObjectiveThrough targeted metabolomics analysis, we examined the liver sugar and acylcarnitine metabolism responses to supranutritional selenomethionine supplementation in pigs.MethodsThirty-six castrated male pigs were fed SeMet adequate or SeMet supranutritional diets for 60 d. The Se concentration, biochemical, gene expression, enzyme activity, and energy-targeted metabolite profiles were analyzed.ResultsThe...
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