• Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort

    2 monthes ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundStudies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors.ObjectiveIn this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma in the European Prospective Investigation into Cancer and Nutrition cohort.DesignWithin a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares analysis related 7 modified healthy lifestyle index variables (diet, BMI, physical activity...
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  • Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea trial

    2 monthes ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundThe role of trimethylamine-N-oxide in type 2 diabetes is currently partially understood and controversial.ObjectiveThe aim of this study was to investigate associations between TMAO and related metabolites with T2D risk in subjects at high risk of cardiovascular disease.DesignThis is a case-cohort design study within the Prevención con Dieta Mediterránea study, with 251 incident T2D cases and a random sample of 694 participants without T2D at baseline. We used liquid chromatography-tandem mass spectrometry to measure plasma TMAO, l-carnitine, betaine...
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