• Ipragliflozin enhances glycemic management, but fails to curb appetite

    4 days ago - By Healio

    The SGLT2 inhibitor ipragliflozin can help adults with type 2 diabetes to meet glycemic and weight targets, although it may not alter feelings of hunger, according to findings presented in the Journal of Diabetes Investigation.
    Kazuhiko Sakaguchi, PhD, an associate professor in the department of internal medicine, division of diabetes and endocrinology at Kobe University Graduate School of Medicine in Japan, and colleagues conducted a multicenter, open-label clinical trial by recruiting 96 adults with type 2 diabetes with HbA1c levels between 6.5% and 9.5% and a BMI of at least 22 kg/m2 (mean
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  • Atrasentan Back on the SONAR for Diabetes and Kidney Disease

    4 days ago - By Medscape

    A trial of the experimental drug suggests major benefits for patients with diabetes and chronic kidney disease, an analysis of data conducted after the SONAR study was halted shows.
    Medscape Medical News
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  • Top stories in cardiology: Age at diabetes diagnosis may impact CV outcomes; app decreases readmissions after MI

    4 days ago - By Healio

    Among the top stories in cardiology last week were findings that suggested the age at type 2 diabetes diagnosis may be important for determining survival and cardiovascular outcomes and preliminary trial results that indicated patients who used an intervention with a smartphone app and an Apple Watch to manage their care after myocardial infarction had a lower risk for being readmitted compared with those treated with usual care.
    Other highlights included a study that found one in five survivors of MI are under age 40, a study that suggested older patients who were predominantly frail and
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  • Surgeons leverage resources to make outpatient surgery safer

    4 days ago - By Healio

    Keeping patients safe during and after orthopedic outpatient surgery of all types - arthroscopy, joint replacement, hand, spine and other procedures -will be of ongoing concern as the frequency with which these procedures are performed increases and anesthesia and surgical protocols evolve. The American Academy of Orthopaedic Surgeons stated in a position statement that with the continued advancement of medical technology comes more opportunities for outpatient surgery to be utilized. However, lingering concerns about the safety of outpatient orthopedic surgery remain.
    “It is
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  • Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

    4 days ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundSaturated fatty acids of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs arachidic acid , behenic acid , and lignoceric acid are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed.ObjectiveWe investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies.MethodsTwelve studies that are part of the Fatty Acids and...
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  • Salivary α-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study

    4 days ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundSeveral studies recently reported contradicting results regarding the link between amylase 1 copy numbers , obesity, and type 2 diabetes.ObjectiveThe aim of this study was to assess the impact of AMY1 CN on anthropometrics and glycemic outcomes in obese individuals following a 2-phase dietary weight loss intervention.MethodsUsing the paralog ratio test, AMY1 CNs were accurately measured in 761 obese individuals from the DiOGenes study. Subjects first underwent an 8-wk low-calorie diet and then were randomly assigned to a 6-mo weight maintenance dietary intervention with...
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  • CREDENCE: Canagliflozin safely reduces risk for ESKD in patients with type 2 diabetes, CKD

    4 days ago - By Healio

    Canagliflozin safely reduced the risk of kidney failure and prevented cardiovascular events in patients with type 2 diabetes and chronic kidney disease, according to phase 3 results from the CREDENCE study presented at a late-breaking clinical trials session at the International Society of Nephrology's World Congress of Nephrology Annual Meeting in Melbourne, Australia.
    “We're looking after an increasing number of patients with diabetes and chronic kidney disease,” David C. Wheeler, MD, FRCP, professor of kidney medicine at University College London, UK, said in a
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