• Insulin Pill May Delay Type 1 Diabetes in Some

    20 days ago - By MedlinePlus

    Related MedlinePlus Pages: Diabetes Medicines , Diabetes Type 1
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  • The DIPP project: 20 years of discovery in type 1 diabetes

    The DIPP project: 20 years of discovery in type 1 diabetes

    20 days ago - By MedWorm


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  • Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity

    20 days ago - By MedWorm

    ConclusionsClass II HLA genotype groups improve the estimation of T1D risk. Class II effect is limited to the early phase of the disease process characterized by seroconversion for islet autoantibodies.
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  • Role of humoral beta‐cell autoimmunity in type 1 diabetes

    20 days ago - By MedWorm

    Islet cell antibodies were found for the first time more than 40 yr ago in patients with autoimmune endocrine deficiencies, including type 1 diabetes. ICA detected by indirect immunofluorescence represent a heterogeneous group of autoantibodies targeting a series of biochemical autoantigens, such as the protein tyrosine phosphatase related islet antigen 2 , the 65 kD isoform of glutamic acid decarboxylase , and zinc transporter 8 as well as currently unidentified autoantigens. The general view is that the diabetes‐associated autoantibodies are not directly involved in beta‐cell destruction...
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  • Dysregulation of glucose metabolism in preclinical type 1 diabetes

    20 days ago - By MedWorm

    Long‐term prospective studies have provided valuable information about preclinical type 1 diabetes. Children who have seroconverted to positive for islet autoantibodies have also, in follow‐up, had metabolic tests to understand the timing and development of abnormal glucose tolerance and declining insulin secretion before the clinical diagnosis of T1D. First phase insulin response in the intravenous glucose tolerance test is lower in the progressors positive for multiple islet autoantibodies in all age groups and as early as 4-6 years before the diagnosis when compared with the...
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