• ‘Distinct genetic architectures' between sexes lead to opposite testosterone effects on diabetes risk

    3 days ago - By Healio

    Women are more likely and men less likely to develop type 2 diabetes if they have elevated levels of testosterone, which may be partially explained by distinct genetic makeups for regulating sex hormones, according to findings published in Nature Medicine.
    John R. B. Perry, PhD, of the Medical Research Council Epidemiology Unit at the University of Cambridge, and colleagues used data on testosterone, estradiol and sex hormone-binding globulin levels from 425,097 adults from the UK Biobank. The researchers also examined genetic data from which they “identified 2,571 genome-wide
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