• With CRISPR, Scientists Engineered Nearly 4,000 Mutations of a Breast-Cancer Gene

    2 monthes ago - By The Atlantic

    BRCA1 is one of the best-studied cancer genes in the world. Still, on occasion, doctors will test a patient and find a BRCA1 mutation no one has ever seen before. This creates a dilemma. The newly discovered “ variant of unknown significance ,” or VUS, could be harmful, making a woman's risk of developing breast cancer as high as 72 percent. Or it could be nothing to worry about at all. “You hear these horror stories about people who have a VUS,” says Fergus Couch , a breast-cancer researcher at Mayo Clinic. “They have the surgery”-to preemptively remove their breasts-“because they're...
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