• Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology

    27 days ago - By ScienceDaily

    Researchers have built an interactome that includes the lung-epithelial cell host interactome integrated with a SARS-CoV-2 interactome. Applying network biology analysis tools to this human/SARS-CoV-2 interactome has revealed potential molecular mechanisms of pathogenesis for SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The research identified 33 high-value SARS-CoV-2 therapeutic targets, which are possibly involved in viral entry, proliferation and survival to establish infection and facilitate disease progression.
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  • Researchers find diminished response by 'killer' T cells in elderly COVID-19 patients

    27 days ago - By ScienceDaily

    Although people of any age can become infected with SARS-CoV-2, the virus that causes COVID-19, elderly patients face a higher risk of severity and death than younger patients. New research comparing the immune response among age groups may help explain why. Older patients with the disease have lower frequencies of the immune cells needed to expel the virus from the body, the researchers found.
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  • SARS-CoV-2 during pregnancy not associated with complications in neonates, study finds

    27 days ago - By ScienceDaily

    In a new study, researchers examined the association between a positive SARS-CoV-2 test during pregnancy and complications in mothers and their newborn babies. Almost two out of three pregnant women who tested positive for SARS-CoV-2 were asymptomatic and the researchers found no higher prevalence of complications during delivery or of ill-health in the neonates. However, preeclampsia was more common in infected women.
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  • Glycans in the SARS-CoV-2 spike protein play active role in infection

    27 days ago - By ScienceDaily

    Many efforts to develop vaccines and therapies to thwart SARS-CoV-2 focus on the coronavirus spike protein, which binds the angiotensin-converting enzyme 2 on human cells to allow viral entry. Now, researchers have uncovered an active role for glycans - sugar molecules that can decorate proteins - in this process, suggesting targets for vaccines and therapies.
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