• Oct-4 is highly expressed in stem/progenitor cells and in primordial follicles of the fetal human ovary

    1 month ago - By Journal of Pediatric and Neonatal Individualized Medicine

    Oct-4 is a member of the POU family. During development, Oct-4 is expressed in embryonic stem cells and in germ cell precursors. In this study, we investigated the expression of Oct-4 in the ovaries of human fetuses during gestation. The ovaries of 14 human fetuses and newborns, ranging in gestational age from 12 up to 38 weeks of gestation, were formalin-fixed, routinely processed and paraffin-embedded. Paraffin sections were immunostained with an anti-Oct-4 commercial antibody. Oct-4 expression was demonstrated in all the ovaries analyzed. Immunoreactivity for Oct-4 was detected in...
    Read more ...