• Hypothermia Plus Melatonin in Asphyctic Newborns: A Randomized-Controlled Pilot Study

    2 days ago - By Pediatric Critical Care Medicine

    Objectives:
    To investigate the effect of adding melatonin to hypothermia treatment on neurodevelopmental outcomes in asphyctic newborns.
    Design:
    Pilot multicenter, randomized, controlled, double-blind clinical trial. Statistical comparison of results obtained in two intervention arms: hypothermia plus placebo and hypothermia plus melatonin.
    Setting:
    Level 3 neonatal ICU.
    Patients:
    Twenty-five newborns were recruited.
    Interventions:
    The hypothermia plus melatonin patients received a daily dose of IV melatonin, 5 mg per kg body weight, for 3 days. General laboratory variables were measured...
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